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5-AMINO-1MQ
  • 5-AMINO-1MQ
  • 5-AMINO-1MQ
5-AMINO-1MQ
$ 2,900.00 $ 4,000.00
$ 2,900.00 MXN
$ 2,465.00 MXN

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5-Amino-1MQ is a selective, membrane-permeable small molecule inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT). In metabolic research, it is utilized to investigate the kinetics of the NAD+ salvage pathway and the regulation of lipogenic gene expression in adipocytes. Supplied as a pre-measured encapsulated reagent (>99% purity) designed for precise laboratory dosing and in vitro analysis. Strictly for laboratory use only.

CAS Number: 4236-29-5
Format: Encapsulated Enzyme Inhibitor

Chemical Description

5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic quinolinium derivative engineered to function as a specific inhibitor of cytosolic Nicotinamide N-methyltransferase (NNMT). By structurally mimicking nicotinamide, it competitively binds to the enzyme, preventing the methylation of nicotinamide into 1-methylnicotinamide (1-MNA). This inhibition preserves the pool of nicotinamide available for the NAD+ salvage pathway. It is a critical reagent for studying cellular bioenergetics and the epigenetic regulation of metabolic pathways in vitro.

Research Applications

This compound is strictly for laboratory research use in the study of:

  • NAD+ Salvage Pathway Kinetics: Investigation of intracellular NAD+ concentrations and the subsequent activation of NAD-dependent enzymes, such as Sirtuin-1 (SIRT1), in metabolic cell models.
  • Adipocyte Bioenergetics: In vitro analysis of lipogenesis markers and mitochondrial oxidation rates in white adipose tissue cultures.
  • Epigenetic Signaling: Research into the role of the metabolite 1-MNA in methylation-dependent gene expression and cellular senescence.

Technical Specifications

  • Molecular Formula: C10H11N2+
  • Molecular Weight: ~159.21 g/mol
  • Purity: >99% (Active Reagent)
  • Format: Research Capsule (Pre-measured for laboratory precision)
  • Solubility: Soluble in water and organic solvents

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Presentation & Handling

  • Form: Oral capsules.
  • Storage: Store in a cool, dry environment, away from heat, light, and moisture.


Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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