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Semax
  • Semax
  • Semax
Semax
$ 2,400.00 $ 2,500.00
$ 2,400.00 MXN
$ 2,040.00 MXN

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Concentration

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the N-terminal fragment of Adrenocorticotropic Hormone (ACTH 4-10). Unlike the parent hormone, this analogue is devoid of corticotropic activity. In neurochemical research, it is utilized to investigate the transcriptional regulation of Brain-Derived Neurotrophic Factor (BDNF) and the modulation of monoaminergic neurotransmitter turnover in striatal tissue models. Supplied as a high-purity (>99%) lyophilized reagent strictly for laboratory analysis.

Reconstitution Volume:
2 mL

Type of Diluent:
Bacteriostatic Water

Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Format: Synthetic ACTH(4-10) Analogue

Chemical Description

Semax is a synthetic heptapeptide consisting of the ACTH(4-10) fragment extended at the C-terminus by a Pro-Gly-Pro tripeptide. This structural modification significantly enhances its enzymatic stability against peptidases compared to the natural hormone fragment. Chemically, Semax acts as a melanocortin receptor ligand and a regulator of gene expression. It is extensively studied for its ability to rapidly induce the synthesis of neurotrophins (BDNF, NGF) and modulate the expression of genes involved in the immune response and vascular regulation in vitro.

Research Applications

This compound is strictly for laboratory research use in the study of:

  • Neurotrophin Expression Kinetics: Quantification of rapid BDNF and NGF mRNA upregulation in the hippocampus and basal forebrain of explant models.
  • Neuroprotection Assays: In vitro analysis of neuronal survival rates and oxidative stress markers in cells subjected to hypoxia or glucose deprivation.
  • Monoaminergic Turnover: Research into the modulation of extracellular levels of dopamine and serotonin metabolites (DOPAC, 5-HIAA) in striatal tissue cultures.

Technical Specifications

  • Molecular Formula: C37H51N9O10S
  • Molecular Weight: 813.9 g/mol
  • Purity: >99% (determined by HPLC)
  • Appearance: Lyophilized White Powder
No analysis is available for this product.

Presentation & Handling

  • Form: Supplied as lyophilized peptide in sterile vial.
  • Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
  • Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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