PEPTIDES4ALL Thymalin – Synthetic Thymic Peptide for Immune, Regenerative & Longevity Research

PEPTIDES4ALL Thymalin is a synthetic peptide complex originally isolated from calf thymus tissue and now refined into a high-purity research reagent to explore fundamental mechanisms of immune regulation, cellular regeneration, and age-related decline. Research shows that Thymalin can normalize function in immune-compromised or senescent systems by influencing key gene expression pathways, cytokine regulation, hematopoiesis, and cellular apoptosis. PMC+1
At the molecular level, Thymalin and its constituent di-/tri-peptides (such as the KE and EW sequences) have been shown to bind to double-stranded DNA or histone proteins, modulate expression of heat-shock proteins (HSPs), cytokines, fibrinolysis factors and gerontogenes, and thereby support immune cell differentiation, proliferation and resilience. MDPI+1
This mechanism positions Thymalin as a versatile model compound for investigating the interplay between the thymus gland, immune homeostasis, cellular stress responses, and aging physiology—making it relevant for studies of immunosenescence, regenerative therapy, and longevity research.

Scientific Evidence & Research Findings

• Immune Regulation & Hematopoiesis – Thymalin normalizes T- and B-lymphocyte subsets, stimulates phagocytosis and supports hematopoietic recovery after suppression. PMC+1

• Immunomodulation in Viral & Age-Related Contexts – In older patients with severe viral infection (e.g., COVID-19), Thymalin was associated with faster recovery of lymphocyte counts, normalization of inflammatory markers, and reduced mortality compared to standard therapy. PMC+1

• Cellular & Molecular Mechanisms – Research demonstrates modulation of NF-κB signaling, down-regulation of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), and interaction with gene-promoter regions and histone proteins by KE/EW dipeptides. MDPI

• Regenerative & Longevity Effects – Animal and human studies suggest potential geroprotective properties: improvements in immune parameters, restoration of youthful physiological profiles, and reduction in age-related decline in immune function. Peptide Sciences+1

Key Research Benefits & Applications

• Immune Cell Homeostasis: Supports research into thymic-derived signaling, T-cell differentiation, NK-cell activation, and immune regeneration.

• Immunosenescence & Aging Models: Offers a model for studying age-related immune decline, hematopoietic suppression, and regenerative capacity.

• Inflammation & Cytokine Modulation: Applicable in research on chronic inflammation, immunopathology, acute infection responses, and cytokine regulation.

• Regenerative Medicine & Hematopoiesis: Useful for exploring hematopoietic recovery, immune-system resetting post-injury, and tissue regeneration models.

• Longevity Biology: Enables investigation into thymus-derived peptide signalling, gerontogene expression, and cellular resilience pathways.

Presentation & Handling

• Form: Supplied as lyophilized peptide in sterile vial.
• Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
• Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Intended Use

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.