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5-AMINO-1MQ
  • 5-AMINO-1MQ
  • 5-AMINO-1MQ
5-AMINO-1MQ
$ 3,300.00 $ 4,000.00
Food supplement form

5-Amino-1MQ – Oral Supplement for Metabolic, Longevity & Performance Research

5-Amino-1MQ is a small-molecule NNMT inhibitor studied for its ability to preserve NAD⁺ levels, enhance cellular energy balance, and support metabolic health. By blocking nicotinamide N-methyltransferase (NNMT), it helps redirect nicotinamide toward NAD⁺ biosynthesis—an essential cofactor for mitochondrial function, energy production, and cellular repair.

In preclinical research, 5-Amino-1MQ has demonstrated reductions in fat mass, improved insulin sensitivity, and restoration of liver metabolic profiles, particularly when combined with balanced nutrition. Studies also suggest potential benefits for muscle performance and recovery in aging models when paired with physical activity, highlighting its relevance in metabolic and longevity research.

Each capsule is produced in research-grade purity, providing a reliable and consistent formulation for exploring energy metabolism, NAD⁺ regulation, and body-composition mechanisms in scientific studies.

PEPTIDES4ALL 5-Amino-1MQ – Orally Active NNMT Inhibitor for Metabolic & Longevity Research

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor developed for the exploration of metabolic regulation, NAD⁺ preservation, and cellular longevity.
By suppressing NNMT activity — an enzyme that diverts nicotinamide away from NAD⁺ salvage — 5-Amino-1MQ helps maintain cellular NAD⁺ pools, enhance energy metabolism, and reduce adipose accumulation.

Elevated NNMT expression has been implicated in obesity, insulin resistance, fatty liver disease, and age-related metabolic dysfunction.
Through its selective inhibition mechanism, 5-Amino-1MQ supports improved mitochondrial function, glucose handling, and metabolic flexibility — positioning it as a valuable compound for obesity, metabolic health, and longevity research. PMC+1

Scientific Rationale & Evidence

  • Reversal of Diet-Induced Obesity — In high-fat diet mouse models, 5-Amino-1MQ significantly reduced adipose tissue mass and improved metabolic markers without affecting food intake. PMC

  • Improved Metabolic & Liver Pathology — In obese mice, combining 5-Amino-1MQ with a lean diet restored adiposity and liver pathology to lean control levels, suggesting synergy with dietary modulation. Nature

  • Mechanism: NAD⁺ Preservation — By inhibiting NNMT, 5-Amino-1MQ limits nicotinamide methylation (forming 1-methyl nicotinamide), thereby preserving nicotinamide availability for NAD⁺ salvage pathways. Peptide Sciences+1

  • Muscle Strength / Repair Effects — Recent insights show that in aged mice, treatment with 5-Amino-1MQ improved grip strength and enhanced recovery when combined with exercise, supporting its potential in muscle resilience research. NMN.com

Key Research Benefits & Applications

  • NAD⁺ Preservation & Energy Metabolism — Inhibits NNMT to sustain NAD⁺ salvage, supporting mitochondrial efficiency and ATP synthesis.

  • Adipose Reduction & Metabolic Regulation — Promotes lipolysis and reduces fat storage in obesity and insulin-resistance models.

  • Improved Insulin Sensitivity — Enhances glucose uptake and metabolic balance in skeletal muscle and liver tissue.

  • Muscle Recovery & Strength — Supports mitochondrial repair and physical performance in aged or stressed subjects.

  • Cellular Longevity & Repair — Provides a model for studying NAD⁺-linked pathways of sirtuin activation and anti-aging biochemistry.

  • Translational Potential — Orally bioavailable and suitable for cross-disciplinary metabolic and gerontology research.

Presentation & Handling

  • Form: Oral capsules.
  • Storage: Store in a cool, dry environment, away from heat, light, and moisture.

Intended Use

For research purposes only. Must be handled in accordance with institutional laboratory standards, biosafety regulations, and ethical research protocols.

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