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CJC-1295 (DAC)
  • CJC-1295 (DAC)
  • CJC-1295 (DAC)
CJC-1295 (DAC)
$ 2,100.00 $ 2,500.00
$ 2,100.00 MXN
$ 1,785.00 MXN

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Concentration

CJC-1295 DAC is a synthetic Growth Hormone-Releasing Hormone (GHRH) analogue modified with a Drug Affinity Complex (DAC) moiety. This modification enables specific binding to serum albumin, protecting the peptide from enzymatic degradation by DPP-IV. In pharmacokinetic research, it is utilized to investigate sustained GHRH receptor occupancy and the continuous, non-pulsatile stimulation of somatotrophs. Supplied as a high-purity (>99%) lyophilized reagent strictly for laboratory analysis and bioconjugation studies.

Reconstitution Volume:
2 mL

Type of Diluent:
Bacteriostatic Water

CAS Number: 863288-34-0 (Modified)
Format: Albumin-Binding GHRH Analogue

Chemical Description

CJC-1295 with DAC is a tetrasubstituted analogue of GHRH(1-29) conjugated to a Drug Affinity Complex (DAC). Specifically, it incorporates a lysine linker attached to a reactive maleimidopropionic acid (MPA) group. Upon reconstitution in serum-containing media, this reactive group forms a stable covalent bond with the free thiol group (Cys34) of serum albumin. This bioconjugation significantly increases the molecular weight of the complex, reducing renal clearance and preventing enzymatic cleavage, thereby extending the half-life of the ligand in research environments.

Research Applications

This long-acting peptide is strictly for laboratory research use in the study of:

  • Bioconjugation Kinetics: Investigation of the reaction rate and stability of the maleimide-thiol bond formation with albumin species in vitro.
  • Sustained Receptor Activation: Research into the effects of continuous (non-pulsatile) GHRH receptor stimulation on IGF-1 mRNA transcription levels in hepatocyte models.
  • Proteolytic Stability Assays: Comparative analysis of degradation rates against Dipeptidyl Peptidase-4 (DPP-IV) relative to native GHRH.

Technical Specifications

  • Molecular Formula: C165H269N47O46 (Peptide moiety)
  • Molecular Weight: 3647.28 g/mol
  • Purity: >99% (determined by HPLC)
  • Appearance: Lyophilized White Powder
  • Format: 10mg Vial
No analysis is available for this product.

Presentation & Handling

  • Form: Supplied as lyophilized peptide in sterile vial.
  • Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
  • Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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