PEPTIDES4ALL CJC-1295 No DAC + Ipamorelin – Synergistic Growth Hormone Secretagogue Blend for Regenerative & Metabolic Research

PEPTIDES4ALL introduces a dual-peptide formulation combining CJC-1295 No DAC (MOD-GRF 1-29) and Ipamorelin in a single 10 mg lyophilized vial (5 mg + 5 mg). This advanced research blend is designed for studies exploring synergistic stimulation of growth hormone (GH) release, cellular regeneration, metabolic regulation, and recovery mechanisms.

CJC-1295 No DAC is a synthetic growth-hormone-releasing hormone (GHRH) analogue engineered for pulsatile GH stimulation, supporting a physiological secretion pattern without sustained elevation. Research suggests it may promote muscle growth, enhanced metabolism, and tissue repair.

Ipamorelin is a selective GH secretagogue that mimics ghrelin’s action to trigger natural GH release through the GHS-R receptor, with minimal impact on cortisol or prolactin. Studies have highlighted its potential in muscle recovery, fat metabolism, and anti-aging applications. (PubMed:9849822; ResearchGate:13437588)

Together, these peptides demonstrate complementary mechanisms, amplifying growth-hormone output while maintaining a controlled and balanced hormonal profile—ideal for exploring GH optimization, cellular repair, and metabolic health.

Scientific Evidence & Research Findings

Extensive preclinical and clinical research supports the synergistic effects of combining a GHRH analogue (CJC-1295 No DAC / MOD-GRF 1-29) with a GHRP (Ipamorelin) for enhanced growth hormone secretion, improved tissue repair, and optimized metabolic balance.
Together, these peptides activate two distinct but complementary receptor systems that control GH release — the GHRH receptor and the ghrelin receptor (GHS-R1a) — producing physiologic pulsatile GH elevation rather than continuous stimulation.

• Dual Receptor Synergy:
  CJC-1295 No DAC stimulates the GHRH receptor, initiating GH synthesis and pituitary release, while Ipamorelin activates GHS-R1a, amplifying the amplitude and duration of GH pulses. Their combined use produces additive or synergistic GH peaks, mimicking the body’s natural rhythm (PMC:1289271/)

• Physiologic GH Pulsatility:
  Unlike CJC-1295 DAC, which is known to support sustained GH levels over several days yet preserve pulsatile GH secretion patterns (Pulsatile Secretion of GH Persists during Continuous Stimulation) (PubMed: 17018654), the No DAC variant with its ~30-minute half-life is better suited to model physiologic GH pulses, allowing study of feedback dynamics and receptor sensitivity..

• Selective & Safe Endocrine Profile:
  Ipamorelin uniquely triggers GH secretion without elevating ACTH, prolactin, or cortisol, distinguishing it from other secretagogues like GHRP-2 or hexarelin (https://academic.oup.com/jcem/article-abstract/89/5/2290/2844515).

• Metabolic & Regenerative Implications:
  Independent and combination studies indicate potential benefits for lean mass accrual, lipolysis, and connective-tissue recovery, driven by GH-dependent increases in IGF-1 synthesis and protein turnover.
  Models also show improved mitochondrial metabolism, wound healing, and insulin sensitivity in GH-optimized environments (https://academic.oup.com/endo/article-abstract/140/8/3581/2990691).

Together, these complementary peptides offer a powerful model for exploring the interplay between neuroendocrine signaling, tissue regeneration, and metabolic homeostasis.

Key Research Benefits & Applications

• Synergistic GH Release — Dual activation of GHRH and GHS-R1a receptors produces amplified, physiologic GH pulses with controlled amplitude and duration.
• Muscle Growth & Tissue Repair — Promotes lean-mass development, protein synthesis, and regenerative recovery through GH- and IGF-1-mediated pathways.
• Metabolic Optimization — Enhances fat oxidation, glucose handling, and insulin sensitivity; valuable for metabolic and longevity research.
• Neuroprotective & Recovery Applications — Supports mitochondrial function, myocellular regeneration, and systemic recovery after injury.
• Endocrine Precision & Safety — Selectively elevates GH without increasing cortisol or prolactin, reducing hormonal interference.
• Model for Pulsatile GH Dynamics — Enables studies on receptor feedback, circadian timing, and GH rhythm desensitization in aging models.
• Potential Research Domains — Metabolic disorders, sarcopenia, wound healing, endocrine optimization, and peptide-based regenerative therapy.

Presentation & Handling

• Form: Supplied as lyophilized peptide in sterile vial.
• Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
• Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Intended Use

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.