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DERMA-REGEN

DERMA-REGEN IM is a sterile intramuscular injectable research blend formulated to support skin repair, barrier resilience, cellular regeneration, and dermatologic metabolism. Combining niacinamide (50 mg), thiamine HCl (50 mg), pantothenic acid (25 mg), choline (10 mg), inositol (10 mg), niacin (5 mg), biotin (100 µg), folic acid (100 µg), and riboflavin (100 µg), this comprehensive B-vitamin matrix may help:

  • Provide cofactors for DNA repair and cellular energy metabolism
  • Enhance barrier lipid synthesis and ceramide formation
  • Moderate oxidative and inflammatory stress in skin cell populations
  • Support keratinocyte / fibroblast renewal under experimental skin damage or aging protocols

Ideal for use in preclinical dermatologic models, skin aging research, barrier impairment studies, and investigative skin health protocols, DERMA-REGEN IM offers a robust, injectable vector for exploring micronutrient-driven skin interventions.

Research use only — not for human or veterinary application.

PEPTIDES4ALL DERMA-REGEN – Intramuscular Dermatologic & Skin Renewal Blend

DERMA-REGEN is a sterile intramuscular (IM) injectable formulation combining a spectrum of B-vitamins and related compounds designed to support skin repair, barrier function, cellular energy, and dermatologic resilience. Formulated for research use only, this blend is intended for preclinical and in vivo/in vitro studies probing the intersection of micronutrient support and skin health under stress, aging, or damage paradigms.

Composition (per dose):

  • Niacinamide 50 mg

  • Thiamine HCl 50 mg

  • Pantothenic Acid (Vitamin B5) 25 mg

  • Choline 10 mg

  • Inositol 10 mg

  • Niacin (Vitamin B3) 5 mg

  • Biotin 100 µg

  • Folic Acid 100 µg

  • Riboflavin (Vitamin B2) 100 µg


Scientific Evidence & Research Findings

Niacinamide (50 mg) / Niacin (5 mg)

  • Niacinamide (vitamin B3) is well studied in dermatology for its barrier-repair, anti-pigmentation, anti-inflammatory, and antioxidative effects. MDPI+3PMC+3PMC+3

  • Clinical trials using topical 4% niacinamide showed reduction in hyperpigmentation (melasma), reduced inflammation, and improved skin appearance. PMC

  • Niacinamide also modifies NF-κB and MAPK signaling, suppressing cytokines like IL-8, IL-6, TNF-α in keratinocytes under stress or UV insult. PMC+1

  • Niacinamide has been associated with improved skin hydration via increased ceramide synthesis and barrier lipids. MDPI+3DermNet®+3ScienceDirect+3

  • A high-quality trial of nicotinamide (oral) in humans reduced incidence of new non-melanoma skin cancers by ~23% in high-risk patients. UNSW Sites

 

B-Vitamin Complex (Thiamine, Pantothenic Acid, Riboflavin, Biotin, Folic Acid, Choline, Inositol)

  • B vitamins are essential cofactors in energy metabolism (e.g. NAD, FAD, CoA), nucleotide synthesis, methylation, and cellular repair pathways. pagepress.org+3Consensus+3PMC+3

  • In dermatology reviews, the vitamin B group is discussed as supportive in acne, dermatitis, and general skin homeostasis, though often in oral or topical contexts rather than injected forms. PMC+2PubMed+2

  • Riboflavin and folate are vital for repair of oxidative damage and cellular replication in skin cells. PMC+1


Key Research Benefits & Applications

  • Barrier & Repair Support: Niacinamide plus B vitamins may provide substrates for DNA repair, lipid synthesis (ceramides), and antioxidant resilience in skin tissue under oxidative or UV insult.

  • Energy & Biosynthesis: The B vitamin complex supports mitochondrial metabolism, coenzyme function (NAD, FAD, CoA), and anabolic pathways necessary for cell renewal.

  • Anti-Inflammatory & Redox Regulation: Niacinamide modulates inflammatory pathways and reduces oxidative stress in epidermal and dermal cells; cofactor vitamins further support redox enzymes.

  • Synergistic Blend: The combination is intended to deliver a broader coverage across multiple biochemical pathways that influence skin quality and resilience, beyond what a single vitamin can accomplish.


Formulation, Handling & Storage

  • Formulation: Sterile, preservative-free IM injectable solution
  • Administration: Intramuscular injection (e.g. deltoid, gluteal) under sterile technique
  • Storage: –20 °C, shielded from light and moisture; handle under lab protocols 

Intended Use 

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.

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