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GHK-CU
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Concentration

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring tripeptide with a high affinity for copper(II) ions. In laboratory settings, this compound is utilized to investigate extracellular matrix remodeling, specifically the upregulation of collagen synthesis pathways and the modulation of metalloproteinase activity in fibroblast cultures. Supplied as a high-purity (>99%) blue lyophilized powder strictly for in vitro analysis and development. Strictly for laboratory use.

Reconstitution Volume:
3 mL

Type of Diluent:
Bacteriostatic Water

CAS Number: 49557-75-7
Sequence: (Gly-His-Lys)2Cu

Chemical Description

GHK-Cu is a synthetic copper-binding tripeptide complex consisting of the amino acids Glycine, Histidine, and Lysine. It is characterized by its strong affinity for Copper(II) ions, forming a stable coordination complex. In biochemical research, GHK-Cu is studied for its ability to facilitate copper uptake into cells and its role as a signal peptide in the regulation of Extracellular Matrix (ECM) proteins, including collagen and elastin, within in vitro models.


Research Applications

This compound is strictly for laboratory research use in the study of:

  • Fibroblast Signaling: Investigation of signal transduction pathways leading to the synthesis of Collagen Type I and III in dermal fibroblast cultures.
  • Metalloproteinase Regulation: In vitro analysis of the modulation of Tissue Inhibitors of Metalloproteinases (TIMPs) and matrix degradation kinetics.
  • Antioxidant Mechanisms: Research into the chelation properties of the peptide and its effect on superoxide dismutase (SOD) activity markers.

Technical Specifications

  • Molecular Formula: C14H24N6O4Cu
  • Molecular Weight: ~340.5 g/mol (Complex)
  • Purity: >99% (determined by HPLC)
  • Appearance: Lyophilized Blue Powder
No analysis is available for this product.

Presentation & Handling

  • Form: Supplied as lyophilized peptide in sterile vial.
  • Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
  • Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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