CAS Number: 49557-75-7
Sequence: (Gly-His-Lys)2Cu
Chemical Description
GHK-Cu is a synthetic copper-binding tripeptide complex consisting of the amino acids Glycine, Histidine, and Lysine. It is characterized by its strong affinity for Copper(II) ions, forming a stable coordination complex. In biochemical research, GHK-Cu is studied for its ability to facilitate copper uptake into cells and its role as a signal peptide in the regulation of Extracellular Matrix (ECM) proteins, including collagen and elastin, within in vitro models.
Research Applications
This compound is strictly for laboratory research use in the study of:
- Fibroblast Signaling: Investigation of signal transduction pathways leading to the synthesis of Collagen Type I and III in dermal fibroblast cultures.
- Metalloproteinase Regulation: In vitro analysis of the modulation of Tissue Inhibitors of Metalloproteinases (TIMPs) and matrix degradation kinetics.
- Antioxidant Mechanisms: Research into the chelation properties of the peptide and its effect on superoxide dismutase (SOD) activity markers.
Technical Specifications
- Molecular Formula: C14H24N6O4Cu
- Molecular Weight: ~340.5 g/mol (Complex)
- Purity: >99% (determined by HPLC)
- Appearance: Lyophilized Blue Powder
Presentation & Handling
- Form: Supplied as lyophilized peptide in sterile vial.
- Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
- Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.
Disclaimer: For Research Purposes Only
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Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.