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IGF-1LR3
  • IGF-1LR3
  • IGF-1LR3
IGF-1LR3
$ 2,300.00 $ 2,500.00
$ 2,300.00 MXN
$ 1,955.00 MXN

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Concentration

IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1) is a synthetic 83-amino acid analogue of native IGF-1. The Long Arg3 substitution is engineered to significantly reduce the binding affinity to Insulin-like Growth Factor Binding Proteins (IGFBPs) in research models. This compound is primarily utilized in cell culture to investigate sustained signaling via the IGF-1R tyrosine kinase receptor, particularly focusing on the PI3K/Akt/mTOR pathway and its effect on cellular maintenance and energy substrate utilization. Supplied as a high-purity lyophilized reagent strictly for laboratory use only. Strictly for laboratory use only.

Reconstitution Volume:
2 mL

Type of Diluent:
Bacteriostatic Water

Sequence: 83 Amino Acids (Modified)
Format: Receptor Tyrosine Kinase Ligand Analogue

Chemical Description

IGF-1 LR3 is a high-grade synthetic peptide analogue of native Insulin-Like Growth Factor-1. Its structure is modified by the substitution of Arginine for Glutamic acid at position 3 and an additional thirteen N-terminal residues. This engineering significantly alters its pharmacological profile by conferring a drastically reduced binding capacity to the six known Insulin-Like Growth Factor Binding Proteins (IGFBPs). This reduction results in a higher proportion of free, unbound ligand available for sustained activation of the IGF-1 Receptor (IGF-1R), a pivotal receptor tyrosine kinase, allowing for precise studies of prolonged signal transduction in vitro.

Research Applications

This compound is strictly for laboratory research use in the study of:

  • Receptor Tyrosine Kinase Signaling: Investigation of sustained activation and downstream effects of the IGF-1R on cellular proliferation and differentiation markers.
  • PI3K/Akt/mTOR Cascade: Analysis of the highly conserved signaling pathway linking nutrient sensing to cellular maintenance and metabolic substrate utilization in cultured cells.
  • Extracellular Matrix Protein Expression: Research into the effects of prolonged IGF-1 signaling on connective tissue fibroblast activity and protein turnover, independent of IGFBP regulation.

Technical Specifications

  • Molecular Weight: 9200 g/mol
  • Purity: >98% (determined by HPLC/MS)
  • Format: Lyophilized Recombinant Peptide
  • Appearance: Lyophilized White Powder
No analysis is available for this product.

Presentation & Handling

  • Form: Supplied as lyophilized peptide in sterile vial.
  • Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
  • Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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