PEPTIDES4ALL J147 – Neuroprotective Small Molecule for Cognitive & Aging Research

J147 is a synthetic small molecule derived from curcumin-based neurotrophic scaffolds, engineered for enhanced brain bioavailability and mitochondrial activity modulation.
Developed to penetrate the blood–brain barrier and target age-associated neurodegenerative mechanisms, J147 represents a next-generation research compound at the intersection of cognitive enhancement, mitochondrial biology, and longevity science.

At the cellular level, J147 acts as a neuroprotective and metabolic regulator, influencing pathways linked to energy balance, oxidative stress resistance, and synaptic repair.
By interacting with mitochondrial ATP synthase (ATP5A) and activating AMPK/mTOR signaling, J147 helps maintain neuronal energy homeostasis and protect against cognitive decline — making it a highly valuable model for studies on Alzheimer’s disease, aging, and neurodegeneration. ScienceDirect+4BioMed Central+4Alzheimer's Drug Discovery Foundation+4

Scientific Evidence & Research Findings

• Mitochondrial Targeting & AMPK/mTOR Activation
  J147 partially inhibits ATP synthase subunit α (ATP5A), leading to downstream activation of the CAMKK2 → AMPK → mTOR pathway. This shift in metabolic signaling is implicated in age-modulation and neuroprotective effects. ScienceDirect+3Alzheimer's Drug Discovery Foundation+3BioMed Central+3

• Cognitive Improvement & Alzheimer’s Models
  In aged rodents and transgenic AD mice, J147 rescued memory and cognition deficits, reduced soluble Aβ levels, and increased synaptic marker expression. Springer Medizin+3PMC+3Alzheimer's Drug Discovery Foundation+3

• Traumatic Brain Injury & Neuroprotection
  Recent data demonstrates that J147 can mitigate secondary damage after TBI and promote functional recovery in rodent models. ScienceDirect

• Safety & Pharmacokinetics
  J147 demonstrates improved bioavailability (≈ 28% in mice) and a plasma half-life of ~2.5 hours. Metabolite studies show the hydrazone scaffold remains intact, and no major toxic byproducts have been identified thus far. Alzheimer's Drug Discovery Foundation+1

• Other Effects
  It also affects fatty acid metabolism, preserves blood–brain barrier integrity, modulates vascular perfusion in brain, and exerts anti-inflammatory effects in hippocampal tissue. BioMed Central+1

Key Research Benefits & Applications

• Cognition & Memory Rescue — restores performance in object recognition, maze tasks, and spatial memory tests in aged and disease models

• Neuroprotective & Anti-degenerative — protects neurons from oxidative stress, amyloid toxicity, and metabolic decline

• Metabolic & Mitochondrial Support — rebalances energy pathways, reduces fatty acids, and regulates mitochondrial stress

• Blood–Brain Barrier & Vascular Support — protects barrier permeability and improves cerebral circulation

• Well-tolerated in preclinical models — no significant toxicity reported in animal studies to date

Presentation & Handling

• Form: Oral capsules.
• Storage: Store in a cool, dry environment, away from heat, light, and moisture.

Intended Use

For research purposes only. Must be handled in accordance with institutional laboratory standards, biosafety regulations, and ethical research protocols.