PEPTIDES4ALL KPV (Lysine-Proline-Valine) – Tripeptide for Anti-Inflammatory & Tissue Repair Research

PEPTIDES4ALL KPV is a synthetic tripeptide derived from the C-terminal fragment of α-melanocyte-stimulating hormone (α-MSH), a peptide known for its broad regulatory roles in immunity, inflammation control, and tissue regeneration. Composed of the amino acids Lysine-Proline-Valine, KPV represents the biologically active segment of α-MSH responsible for many of its anti-inflammatory and immunomodulatory effects.

Unlike traditional anti-inflammatory agents that broadly suppress immune activity, KPV selectively attenuates inflammatory signaling while preserving normal immune function, making it a valuable research tool for exploring inflammatory disorders, mucosal healing, and epithelial repair mechanisms. Through interactions with melanocortin receptors and cellular signaling pathways such as NF-κB inhibition, KPV helps regulate cytokine production, oxidative stress, and immune cell recruitment.

Extensive research has demonstrated its potent effects in models of inflammatory bowel disease (IBD), colitis, dermatitis, and wound healing. In these studies, KPV has shown the ability to reduce pro-inflammatory cytokines (including TNF-α, IL-1β, and IL-6), enhance mucosal and epithelial barrier integrity, and accelerate tissue recovery (PMC2431115; Gastroenterology Journal).

A particularly unique feature of KPV is its targeted uptake through the PepT1 transporter, which becomes upregulated in inflamed gut tissue—allowing localized delivery and selective action within the intestinal epithelium. This mechanism has made KPV a promising molecule for studying gut inflammation, epithelial regeneration, and barrier repair (PMC7827684). Additionally, topical and ocular studies show that KPV can promote corneal and dermal healing, reinforcing its potential in skin and wound-healing research (ScienceDirect).

With its small molecular size, stability, and receptor-specific selectivity, PEPTIDES4ALL KPV provides a high-purity, reproducible model peptide for investigating the crossroads between inflammation, immunity, and tissue regeneration, contributing to emerging research in immunomodulation, mucosal repair, and regenerative therapeutics.

Scientific Evidence & Research Findings

• Suppresses Pro-Inflammatory Cytokines – In colitis models, KPV reduced levels of TNF-α, IL-1β, IL-6, and IFN-γ in inflamed tissues, indicating suppression of inflammatory signaling. https://pmc.ncbi.nlm.nih.gov/articles/PMC2431115/

• PepT1-Mediated Uptake & Gut Targeting – KPV enters epithelial and immune cells in inflamed colon via the peptide transporter PepT1, which is upregulated during intestinal inflammation, offering a targeted anti-inflammatory effect. https://pmc.ncbi.nlm.nih.gov/articles/PMC2431115/

• Models of IBD & Colitis – In murine colitis models, KPV treatment led to reduced intestinal inflammation, improved mucosal healing, and lower inflammatory infiltrates. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827684/

• Skin & Wound Applications – Studies have shown that topical KPV (α-MSH fragment) can promote corneal healing and reduce local inflammation in ocular tissues. https://www.sciencedirect.com/science/article/abs/pii/S0014483506003150

• NF-κB Pathway Modulation – KPV has been shown to inhibit NF-κB activation, a central pathway in inflammatory gene expression, thereby reducing cytokine synthesis. https://www.gastrojournal.org/article/S0016-5085(07)01852-5/fulltext

Key Research Benefits & Applications

• Targeted Anti-Inflammatory Activity: Selectively suppresses pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IFN-γ) through NF-κB pathway inhibition, without compromising overall immune competence.

• PepT1-Mediated Cellular Uptake: Leverages the PepT1 transporter, which is upregulated in inflamed tissues, enabling localized delivery and enhanced bioavailability within the intestinal and epithelial lining.

• Mucosal & Gut Barrier Protection: Promotes epithelial regeneration, tight-junction restoration, and mucosal healing in inflammatory bowel and colitis models.

• Skin, Ocular & Wound Repair: Demonstrates epithelial migration, collagen reorganization, and reduced inflammation in skin and corneal healing studies, supporting applications in dermatology and ophthalmic research.

• Immunomodulatory Precision: Fine-tunes cytokine and chemokine signaling to resolve inflammation rather than suppress immune defense, reflecting a balanced anti-inflammatory mechanism.

• Applications in Regenerative & Inflammatory Research: Provides a reliable model for exploring inflammation resolution, epithelial barrier integrity, and peptide-based immunotherapy in mucosal and systemic settings.

Presentation & Handling

• Form: Supplied as lyophilized peptide in sterile vial.
• Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
• Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Intended Use

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.