PEPTIDES4ALL LL-37 – Human Antimicrobial Peptide for Immunity & Regeneration Research

PEPTIDES4ALL LL-37 is a human cathelicidin-derived antimicrobial peptide that plays a central role in innate immunity, host defense, and tissue regeneration. Produced by immune cells (such as neutrophils and macrophages) and epithelial cells across the skin, lungs, and mucosal surfaces, LL-37 is one of the body’s most versatile defense molecules—acting at the intersection of antimicrobial protection, inflammation control, and wound repair.

Unlike conventional antibiotics that act exclusively on pathogens, LL-37 not only kills microbes directly but also modulates the host immune response, promoting a balanced and adaptive defense. It exerts broad-spectrum antimicrobial activity against bacteria (both Gram-positive and Gram-negative), viruses, and fungi, including antibiotic-resistant strains (PMC3699762). Through membrane pore formation, LL-37 disrupts microbial cell integrity, while its ability to inhibit and penetrate biofilms enhances its effectiveness in chronic and hard-to-treat infections (Nature Reviews Microbiology; Scientific Reports).

Beyond its antimicrobial activity, LL-37 has become a molecule of great interest in tissue regeneration and immunomodulation research. Studies demonstrate that LL-37 stimulates angiogenesis, accelerates epithelial repair, and enhances wound healing, making it highly relevant in fields such as dermatology, regenerative medicine, and diabetic ulcer care (Springer Dermatology Research). Importantly, LL-37 does not broadly suppress the immune system; rather, it fine-tunes inflammatory responses, helping maintain immune balance and tissue homeostasis (ScienceDirect).

Emerging studies have also revealed LL-37’s role as a potential immunotherapeutic peptide, capable of activating dendritic cells, modulating tumor microenvironments, and potentially enhancing anti-cancer immune responses (Frontiers in Pharmacology).

With its high purity, natural origin, and multifaceted biological properties, PEPTIDES4ALL LL-37 serves as a powerful research tool for studying innate immune mechanisms, host-pathogen interactions, epithelial regeneration, and immune-mediated diseases—bridging the gap between antimicrobial defense and regenerative biology.

Scientific Evidence & Research Findings

• Broad-Spectrum Antimicrobial Action – LL-37 kills or inactivates bacteria (Gram-positive and Gram-negative), viruses, and fungi, including antibiotic-resistant strains. https://pmc.ncbi.nlm.nih.gov/articles/PMC3699762/

• Biofilm Disruption & Prevention – It prevents bacterial biofilm formation and helps penetrate existing biofilms, making it effective even against hard-to-treat infections. https://www.nature.com/articles/s41429-018-0090-7

• Membrane Pore Formation Mechanism – LL-37 can form pores in pathogen membranes, causing direct microbial death via membrane disruption. https://www.nature.com/articles/s41598-020-74401-5

• Wound Healing & Tissue Repair – In clinical and animal studies, LL-37 accelerates healing, stimulates angiogenesis (new blood vessel growth), and enhances epithelial regeneration. For example, diabetic foot ulcer patients treated with LL-37 cream showed faster granulation and reduced bacterial colonization. https://link.springer.com/article/10.1007/s00403-023-02657-8

• Immunomodulation Without Broad Suppression – LL-37 modulates inflammatory responses, helping to balance immune activity rather than fully suppressing it. https://www.sciencedirect.com/science/article/abs/pii/S0924857924003145

• Anti-Cancer & Immunostimulation Potential – Some studies suggest LL-37 can function as an immunostimulant in tumor microenvironments, activating dendritic cells and potentially aiding antitumor responses. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.944147/full

Key Research Benefits & Applications

• Broad-Spectrum Antimicrobial Defense: Exhibits potent activity against Gram-positive and Gram-negative bacteria, fungi, and viruses, including multidrug-resistant strains, through direct membrane disruption and immune modulation.

• Biofilm Inhibition & Disruption: Prevents the formation of microbial biofilms and penetrates established colonies, offering a model for studying chronic and antibiotic-resistant infections.

• Wound Healing & Tissue Regeneration: Enhances angiogenesis, epithelial migration, and collagen remodeling, accelerating tissue repair in cutaneous and mucosal injury models.

• Balanced Immune Modulation: Regulates cytokine release, Toll-like receptor signaling, and leukocyte recruitment, maintaining effective immune defense without inducing excessive inflammation.

• Anti-Inflammatory & Antioxidant Effects: Reduces oxidative stress and inflammatory mediators while supporting tissue recovery and immune homeostasis.

• Immunostimulatory & Anti-Cancer Potential: Activates dendritic and natural killer (NK) cells, and has shown tumor-microenvironment immunostimulation in emerging oncological research models.

• Applications in Regenerative & Immunological Research: Serves as a multifunctional peptide model for exploring antimicrobial defense, tissue repair, inflammation resolution, and host–pathogen dynamics.

Presentation & Handling

• Form: Supplied as lyophilized peptide in sterile vial.
• Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
• Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Intended Use

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.