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MOTS-C
  • MOTS-C
  • MOTS-C
MOTS-C
$ 3,500.00 $ 4,100.00
$ 3,500.00 MXN
$ 2,975.00 MXN

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Concentration

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome. In biochemical research, it is identified as a key signaling molecule that translocates to the nucleus to regulate metabolic gene expression. This peptide is utilized in vitro to investigate the activation of the AMP-activated protein kinase (AMPK) pathway and glucose transporter (GLUT4) kinetics in myocyte cultures. Supplied as a high-purity (>99%) lyophilized reagent strictly for laboratory analysis.

Reconstitution Volume:
2 mL

Type of Diluent:
Bacteriostatic Water

Source: Mitochondrial DNA (12S rRNA gene)
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-F-Tyr-Pro-Arg-Lys-Leu-Arg

Chemical Description

MOTS-c is a 16-residue peptide encoded by the mitochondrial 12S rRNA gene. It represents a unique class of mitochondrial-derived peptides (MDPs) that function as retrograde signaling factors, facilitating communication between the mitochondrial genome and the nuclear genome. Biochemically, MOTS-c acts by targeting the folate-methionine cycle and stimulating the phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. This mechanism is studied for its role in modulating acetyl-CoA carboxylase (ACC) activity in vitro.

Research Applications

This mitochondrial peptide is strictly for laboratory research use in the study of:

  • AMPK Pathway Activation: Investigation of the phosphorylation kinetics of AMPK and its downstream effects on fatty acid oxidation markers in skeletal muscle cells.
  • Glucose Transport Kinetics: In vitro analysis of insulin-dependent GLUT4 translocation and glucose uptake rates in adipocyte models.
  • Cellular Senescence: Research into the peptide's influence on metabolic flexibility and senescence-associated secretory phenotypes (SASP) in aging cell lines.

Technical Specifications

  • Molecular Formula: C101H152N28O22S2
  • Molecular Weight: 2174.6 g/mol
  • Purity: >99% (determined by HPLC)
  • Appearance: Lyophilized White Powder
No analysis is available for this product.

Presentation & Handling

  • Form: Supplied as lyophilized peptide in sterile vial.
  • Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
  • Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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