PEPTIDES4ALL NEURO-CALM PM – Intramuscular Neuro-Regulatory & Sleep Modulation Blend

NEURO-CALM PM is a sterile intramuscular (IM) injectable formulation combining GABA (100 mg), Melatonin (1 mg), L-Arginine (100 mg), and L-Glutamine (25 mg). Formulated for research use only, this blend is intended to facilitate investigations into inhibitory neurotransmission, circadian regulation, neural metabolic pathways, and neuroprotective balance in experimental models of sleep disturbance, stress, or neurological dysfunction.

Composition (per dose):

• GABA (γ-Aminobutyric Acid) — 100 mg

• Melatonin — 1 mg

• L-Arginine — 100 mg

• L-Glutamine — 25 mg

Scientific Evidence & Research Findings

GABA & Sleep / Neural Inhibition

• GABA serves as the principal inhibitory neurotransmitter in the central nervous system, modulating neuronal excitability and facilitating calming / relaxation processes. ScienceDirect+1

• In insomnia research, melatonin is thought to potentiate GABAergic signaling by enhancing GABA_A receptor activity and suppressing sympathetic tone. ScienceDirect+1

• Exogenous GABA supplementation has been explored for its sleep benefits, though results are mixed and dependent on formulation, dosage, and blood–brain barrier permeability. Sleep Foundation+1

Melatonin & Circadian / Neural Interaction

• Melatonin is well established for its role in regulating circadian rhythms and promoting sleep onset and quality. ScienceDirect+1

• Several studies show melatonin can upregulate GABA levels in certain brain regions, reinforcing its interaction with inhibitory neurotransmission for anxiolytic and hypnotic effects. PMC+1

Glutamine / Arginine & Neurotransmitter Cycling

• Glutamine acts as a metabolic precursor to both glutamate and GABA, maintaining neurotransmitter pools and supporting synaptic function in the glutamate–GABA–glutamine cycle. Cambridge University Press & Assessment+2PMC+2

• The glutamate/GABA–glutamine cycle integrates neural transmission and metabolic processes, linking excitatory/inhibitory balance with cellular metabolism. PMC+1

• Arginine may influence neural blood flow and metabolic substrate delivery, possibly supporting the function of inhibitory circuits indirectly. (Note: direct potentiation of GABA by arginine has limited direct human evidence in the literature.)

Key Research Benefits & Applications

• Enhanced Inhibition: GABA provides direct inhibitory tone; melatonin amplifies GABAergic signaling and circadian alignment; glutamine replenishes neurotransmitter precursor pools.

• Neuro-metabolic Support: Glutamine–GABA cycling links neural metabolism and inhibitory balance; arginine may support perfusion to central tissues under stress models.

• Sleep & Neural Recovery: This combination acts on both the circadian axis and neurotransmitter inhibition to provide a multi-modal approach to sleep research and neural homeostasis studies.

Formulation, Handling & Storage

• Formulation: Sterile, preservative-free IM injectable solution
• Administration: Intramuscular injection (e.g. deltoid, gluteal) under sterile technique
• Storage: –20 °C, shielded from light and moisture; handle under lab protocols 

Intended Use 

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.