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PNC-27
  • PNC-27
  • PNC-27
PNC-27
$ 4,000.00 $ 6,000.00
$ 4,000.00 MXN
$ 3,400.00 MXN

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Concentration

PNC-27 is a synthetic chimeric peptide containing the p53 residues 12-26 fused to a transmembrane-penetrating domain. In biochemical research, this peptide is utilized to investigate the structural interaction with membrane-bound HDM-2 proteins and the kinetics of transmembrane pore formation in transformed cell lines. Supplied as a high-purity (>99%) lyophilized reagent strictly for in vitro membrane permeability analysis. Strictly for laboratory use only.

Reconstitution Volume:
2 mL

Type of Diluent:
Bacteriostatic Water

Sequence: Pro-Pro-Leu-Ser-Q-E-T-F-S-D-L-W-K-L-L-P + Transmembrane Domain
Format: HDM-2 Binding Peptide

Chemical Description

PNC-27 is a synthetic fusion peptide designed for research into membrane-protein interactions. Structurally, it combines the HDM-2 binding domain of the p53 protein (residues 12-26) with a membrane-residency sequence (MRP). This unique amphipathic structure allows the peptide to bind specifically to HDM-2 proteins located on the plasma membrane of transformed cells. Biochemically, this binding event induces a conformational change that facilitates peptide insertion into the lipid bilayer, leading to the study of pore formation and membrane destabilization kinetics in vitro.

Research Applications

This compound is strictly for laboratory research use in the study of:

  • Membrane Permeability Assays: Investigation of LDH release and transmembrane potential changes in cells expressing high levels of membrane-bound HDM-2.
  • Necrosis Kinetics: In vitro analysis of caspase-independent cell lysis mechanisms and rapid membrane disruption.
  • Protein-Protein Interaction: Research into the binding affinity between p53-derived peptides and the HDM-2 hydrophobic pocket.

Technical Specifications

  • Molecular Formula: C188H293N53O44S
  • Molecular Weight: 4031.8 g/mol
  • Purity: >99% (determined by HPLC)
  • Appearance: Lyophilized White Powder
No analysis is available for this product.

Presentation & Handling

  • Form: Supplied as lyophilized peptide in sterile vial.
  • Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
  • Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Disclaimer: For Research Purposes Only

This content is provided strictly for laboratory research purposes and does not constitute an endorsement or recommendation for any non-laboratory application. The information provided regarding specific peptides is for educational and informational purposes only and must not be construed as medical, clinical, or legal guidance, nor as an encouragement for use in humans or animals.


Peptides described here are solely for use in structured scientific study by qualified researchers. We advise consulting with laboratory safety officers or research experts prior to handling these materials. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice governs all content on this site.

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