CAS Number: 129954-34-3
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Format: Synthetic Neuropeptide (Tuftsin Analogue)
Chemical Description
Selank is a synthetic heptapeptide consisting of seven amino acids, engineered by adding a C-terminal tripeptide extension (Pro-Gly-Pro) to the endogenous immunomodulator tuftsin. This structural modification enhances its stability against proteolytic degradation, allowing for specialized research into regulatory neuropeptide dynamics. Biochemically, it is studied for its capacity to influence the expression of brain-derived neurotrophic factor (BDNF) and interact as an allosteric modulator of the GABA-A receptor complex in vitro.
Research Applications
This neuropeptide is strictly for laboratory research use in the study of:
- Neurotrophic Signaling: Investigation of BDNF mRNA upregulation and its downstream effect on neuronal survival pathways in hippocampal cell lines.
- GABA-A Receptor Kinetics: In vitro analysis of allosteric binding dynamics and the modulation of inhibitory postsynaptic currents.
- Neuroimmune Crosstalk: Research into the peptide's ability to influence cytokine gene expression and restore immune-neural signaling homeostasis under experimental stress models.
Technical Specifications
- Molecular Formula: C33H57N11O9
- Molecular Weight: 751.9 g/mol
- Purity: >99% (determined by HPLC)
- Appearance: Lyophilized White Powder
Presentation & Handling
- Form: Supplied as lyophilized peptide in sterile vial.
- Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
- Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.
Disclaimer: For Research Purposes Only
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