PEPTIDES4ALL Selank – Synthetic Peptide for Neuroprotection, Anxiolysis & Cognitive Research

PEPTIDES4ALL Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from tuftsin, an endogenous tetrapeptide fragment of the immunoglobulin G (IgG) Fc domain that plays a key role in immune regulation and neuroimmune signaling.
Through the addition of a C-terminal tripeptide extension, Selank exhibits enhanced metabolic stability, prolonged CNS bioactivity, and broader neuromodulatory properties than its parent compound.
It represents a distinct class of regulatory neuropeptides that bridge the interface between the nervous and immune systems, making it a valuable model compound for studies in anxiety, stress resilience, neuroplasticity, and cognition.

Selank’s mechanism of action is multifactorial, influencing several major neurochemical and molecular pathways:

• Neurotrophic modulation: Intranasal and parenteral administration of Selank has been shown to increase brain-derived neurotrophic factor (BDNF) mRNA and protein expression in the hippocampus, supporting neuronal survival and synaptic remodeling (ResearchGate).

• Neurotransmitter regulation: Transcriptomic and receptor-binding studies reveal that Selank alters GABAergic, serotonergic, and dopaminergic transmission, modulating genes involved in stress response, mood regulation, and inhibitory signaling (PMC4757669; Frontiers in Pharmacology, 2017).

• GABA-A receptor interaction: Electrophysiological data indicate Selank acts as an allosteric modulator of the GABA-A receptor, enhancing inhibitory tone and contributing to its anxiolytic, stabilizing, and neuroprotective effects without sedative properties typical of benzodiazepines.

• Neuroimmune crosstalk: By influencing cytokine and interferon gene expression, Selank exerts immunomodulatory and anti-inflammatory activity, making it relevant to studies on stress-induced immune dysregulation and neuroinflammation (PMC4757669).

In behavioral and cognitive models, Selank has demonstrated memory-enhancing and anti-anxiety effects, restoring normal BDNF and neurotransmitter signaling disrupted by chronic stress or ethanol exposure (PubMed 31625062).
Its ability to upregulate neurotrophins, stabilize neurotransmission, and modulate immune function positions Selank as a promising peptide for exploring integrative neurobiology — where cognition, emotion, and immunity converge.

With its high purity, defined sequence stability, and reproducible biological activity, PEPTIDES4ALL Selank provides researchers with a precise tool for investigating BDNF-mediated synaptic plasticity, GABAergic modulation, and neuroimmune homeostasis in preclinical models of anxiety, cognitive decline, and neuroprotection.

Scientific Evidence & Research Findings

• Intranasal Selank increases BDNF mRNA and BDNF protein levels in the hippocampus in rat models.
  https://www.researchgate.net/publication/23306196_Intranasal_administration_of_the_peptide_Selank_regulates_BDNF_expression_in_the_rat_hippocampus_in_vivo; ResearchGate

• Selank alters expression of genes related to neurotransmission, stress response, and inflammatory signaling in rodent hippocampus.
  https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/; PMC

• Selank may modulate the GABAergic system: it has been observed to affect GABA_A receptor binding and neuronal inhibition, possibly through allosteric modulation.
  https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00089/full; Frontiers

• In models of ethanol exposure, Selank showed protective effects on memory and cognition, preventing ethanol-induced disruptions in BDNF signaling.
  https://pubmed.ncbi.nlm.nih.gov/31625062/; PubMed

Key Research Benefits & Applications

• Neurotrophic Activation & Synaptic Plasticity: Upregulates brain-derived neurotrophic factor (BDNF) and TrkB signaling, supporting neuronal survival, synaptogenesis, and hippocampal remodeling — key processes in learning and long-term memory.

• GABAergic Modulation & Anxiolytic Action: Functions as an allosteric modulator of the GABA-A receptor, enhancing inhibitory tone and reducing anxiety without sedation, providing a model for non-benzodiazepine anxiolytic mechanisms.

• Monoaminergic Regulation: Influences serotonergic and dopaminergic pathways, stabilizing neurotransmitter dynamics involved in mood regulation, reward processing, and stress adaptation.

• Neuroimmune Balance: Modulates cytokine and interferon-related gene expression, attenuating neuroinflammation and restoring immune–neural homeostasis under stress or inflammatory challenge.

• Cognitive Enhancement & Neuroprotection: Prevents stress- or ethanol-induced cognitive impairment by normalizing BDNF and neurotransmitter signaling, positioning it as a model compound for cognitive resilience and neuroprotective research.

• Integrated Neuroimmune–Endocrine Applications: Ideal for exploring the intersection of emotion, immunity, and cognition, making it a valuable research tool for anxiety, depression, neurodegeneration, and stress physiology studies.

Presentation & Handling

• Form: Supplied as lyophilized peptide in sterile vial.
• Reconstitution: Use bacteriostatic water or 2% procaine; swirl gently (do not shake vigorously).
• Storage: Store at –20 °C, protected from light and moisture. After reconstitution, use according to research protocols and handle under sterile conditions.

Intended Use

For research purposes only. Must be handled in accordance with institutional protocols and ethical guidelines.