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TESOFENSINE
  • TESOFENSINE
  • TESOFENSINE
TESOFENSINE
$ 1,900.00 $ 3,000.00
Food supplement form

Tesofensine 210.25 mg – Oral Supplement for Metabolic & Weight Management Research

Tesofensine is an advanced small-molecule compound researched for its ability to influence appetite, energy balance, and metabolic efficiency through triple monoamine reuptake inhibition—a mechanism that elevates serotonin, dopamine, and norepinephrine levels in key appetite-regulating regions of the brain.

Originally investigated for neurodegenerative studies, Tesofensine has since become a leading focus in metabolic and body-composition research, where it is being studied for its potential to support caloric control, fat-metabolism regulation, and improved energy expenditure.

Each capsule is laboratory-grade and precisely dosed (210.25 mg) to deliver consistent, reproducible results in preclinical or experimental models focused on metabolic signaling, neurotransmitter modulation, and weight-regulation pathways.

PEPTIDES4ALL Tesofensine 210.25 mg – Oral Supplement for Metabolic & Weight Management Research

Tesofensine is a small-molecule triple monoamine reuptake inhibitor that acts by blocking the reuptake of serotonin (5-HT), norepinephrine (NE), and dopamine (DA) — neurotransmitters crucial to appetite regulation and energy balance.
Originally investigated for neurodegenerative diseases such as Parkinson’s and Alzheimer’s, Tesofensine gained prominence when clinical trials revealed profound appetite-suppressing and weight-reducing effects, establishing it as a novel research compound in obesity, metabolism, and neurochemical regulation.

At the mechanistic level, Tesofensine amplifies satiety signals within the hypothalamic appetite centers, enhances energy expenditure, and improves central neurotransmitter tone. These actions contribute to sustained caloric reduction and improved metabolic markers, positioning Tesofensine as an ideal model for studying metabolic homeostasis, neuroendocrine appetite signaling, and energy regulation.

Scientific Evidence & Research Findings

  • Potent Appetite Suppression – In randomized controlled trials, Tesofensine reduced food intake and caloric consumption by enhancing satiety signals through monoamine modulation. Source: Astrup et al., Lancet 2008

  • Weight Loss Efficacy – A 24-week phase II trial reported average weight loss of 10.6 kg with Tesofensine 0.5 mg daily, compared to 2.2 kg with placebo in obese adults. Improvements were dose-dependent and associated with reductions in waist circumference and body fat percentage. Source: Astrup et al., Lancet 2008

  • Improved Metabolic Markers – Beyond weight loss, Tesofensine improved lipid profiles, blood pressure, and insulin sensitivity in some trial arms, making it relevant to research in metabolic syndrome. Source: Finer et al., Obesity 2011

  • Neurochemical Mechanism – By inhibiting reuptake of serotonin, dopamine, and norepinephrine, Tesofensine enhances neurotransmitter availability in appetite-regulating brain regions, contributing to reduced hunger and altered feeding behavior.

Key Research Benefits & Applications

  • Triple Monoamine Reuptake Inhibition — Provides a rare model for studying the combined roles of serotonin, dopamine, and norepinephrine in appetite control and energy metabolism.

  • Metabolic Regulation — Demonstrates measurable effects on lipid metabolism, insulin signaling, and energy expenditure, relevant to obesity and metabolic-syndrome research.

  • Neurochemical Insights — Allows exploration of central reward-pathway modulation in relation to food intake, motivation, and neuroendocrine control.

  • Oral Bioavailability — Designed for systemic absorption and practical integration into chronic-exposure or behavioral-model studies.

  • Reproducible Formulation — High-purity compound produced under controlled laboratory conditions for consistent research performance.

Presentation & Handling

  • Form: Oral capsules.
  • Storage: Store in a cool, dry environment, away from heat, light, and moisture.

Intended Use

For research purposes only. Must be handled in accordance with institutional laboratory standards, biosafety regulations, and ethical research protocols.

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