The SLIM·EDGE Bundle represents a next-generation research system designed to study metabolic acceleration and fat reduction through three complementary mechanisms of action.
By uniting Tirzepatide, 5-Amino-1MQ, and SLU-PP-332, this stack explores how incretin signaling, NNMT inhibition, and mitochondrial receptor activation can synergize to support efficient fat metabolism, muscle retention, and insulin regulation.

🔹 Tirzepatide – Dual Incretin Agonist (GIP + GLP-1)

Tirzepatide is a dual receptor agonist targeting both GLP-1 and GIP, two key incretin pathways that regulate appetite, insulin secretion, and energy balance.
Research has shown Tirzepatide’s potential to significantly reduce body weight, improve glucose tolerance, and enhance insulin sensitivity while maintaining lean mass.
Its dual action promotes satiety, reduced caloric intake, and improved lipid metabolism, making it a cornerstone in modern metabolic studies.

🔹 5-Amino-1MQ – NNMT Inhibition & NAD⁺ Preservation

5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme linked to metabolic slowdown and fat storage.
By suppressing NNMT, it helps increase NAD⁺ availability, enhance mitochondrial energy output, and boost basal metabolic rate.
Research suggests that 5-Amino-1MQ promotes fat loss without muscle catabolism, supports insulin sensitivity, and may counteract age-related metabolic decline.

🔹 SLU-PP-332 – Exercise-Mimetic ERR Pan-Agonist

SLU-PP-332 is a synthetic pan-agonist of the Estrogen-Related Receptors (ERRα, ERRβ, ERRγ), known for activating genes involved in mitochondrial biogenesis, fat oxidation, and metabolic flexibility.
Preclinical studies indicate that SLU-PP-332 acts as an “exercise mimetic”, promoting endurance, fat utilization, and glucose control even in sedentary or high-fat-diet models.
Its ability to enhance cellular respiration and energy turnover makes it an ideal complement to metabolic and longevity research.

Scientific Synergy

Together, these three compounds create a powerful framework for metabolic research:

• Enhances energy metabolism through mitochondrial activation

• Promotes fat oxidation and inhibits new fat formation

• Improves insulin sensitivity and glucose utilization

• Supports lean muscle maintenance during caloric restriction

• Optimizes NAD⁺ and energy balance for cellular efficiency

This synergistic model enables exploration into advanced weight-management strategies, metabolic restoration, and cellular longevity — making SLIM·EDGE one of the most complete metabolic research bundles available.